No link was found between exposure to mobile phones and an increase in cancer, brain function or infertility, after scientists studied hundreds of cases.
However, they will continue to monitor for trends, as little is still known about these new technologies’ long-term effects on our health.
Prof Anthony Swerdlow, who chaired the review group, said "Even though it's relatively reassuring, I also think it's important that we keep an eye on the rates of brain tumours and other cancers," he said.
"One can't know what the long-term consequences are of something that has been around for only a short period."
It is estimated that there are now 80 million mobile phones in the UK – more than the number of people – and with the increase of WiFi zones, television and radio transmissions, humans are exposed to more low-level frequencies than ever before.
It is still recommended by the HPA that children do not use mobile phones excessively.
"As this is a relatively new technology, the HPA will continue to advise a precautionary approach," said Dr John Cooper, director of the HPA's centre for radiation, chemical and environmental hazards.
"The HPA recommends that excessive use of mobile phones by children should be discouraged."