Torrential rain on the Isle and across the south of England has lead to flooding and access problems in Newport, while police were forced to escort many festival goers to Newport Football Club for shelter and refreshments, as the queues towards the site refused to die down overnight.
Queues to get onto the site are estimated to be lasting more than ten hours, while others have been left stranded on ferries from Portsmouth in the terrible weather.
55,000 people are expected on the Isle this weekend for the festival, which was first held in 1968.
Speaking to the BBC, music fan Linda Dawson from Ashurst has been trapped in her car overnight with her family.
She said, "The two things I'm really annoyed about is this weather has been going on for weeks, so why were they not prepared for it? Second we weren't told the full story in Portsmouth and could have turned back if we had known we would be in the car all night.
"Why did they let us get on the ferry when they knew there was nowhere for us to go?" Other festival goers have been asking similar questions of the social networking sites.
According to festival organiser John Giddings, problems started when the main car park flooded, forcing the opening surrounding fields to act as overflows. Cars have had to be towed onto the site, another factor causing delays.
Mr Giddings added, "I'm really very sorry, I can only apologise, I know there's a couple of hundred still out there.”
For anyone who actually gets to the festival, headliners are Bruce Springsteen and Tom Petty.